Dynagen Research Activities
Our research focuses on developping and applying data analysis methods for the understanding of genetic and phenotypic diversity of livestock species and the evolution of their genomes.
Dynamique Evolutive des Génomes
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Séquencer des échantillons anciens stockés en cryobanques pour comprendre comment le génome des animaux domestiques a évolué avec la sélection
Simon Boitard, Laurence Liaubet, Cyriel Paris, Katia Fève, Patrice Dehais, et al. Whole-genome sequencing of cryopreserved resources from French Large White pigs at two distinct sampling times reveals strong signatures of convergent and divergent selection between the dam and sire lines. Genetics Selection Evolution, 2023, 55, pp.13. 10.1186/s12711-023-00789-z hal-04016249
L’étude détaillée de chaque région a également révélé que les signatures de sélection les plus marquées étaient souvent associées à des gènes dont la fonction biologique est particulièrement pertinente pour les caractères sélectionnés. Dans un de ces gènes, IGF2, on observe la sélection d’une mutation génétique affectant la croissance musculaire bien connue dans plusieurs races de porc dont le Large White.
New methods for genotyping honeybee colonies
The honey bee is an eusocial species organized in colonies of several thousand individuals. From a genetic point of view, the founding queen of a colony mates beforehand with several males to constitute a pool of spermatozoa which will be used throughout her life to produce the individuals of the colony. Most of the colony is made up of diploid workers resulting from fertilizations and occasionally of a few haploid males, resulting from an unfertilized gamete of the queen and whose role is only reproductive. In beekeeping, traits of interest for selection are mainly measured at the colony level, whereas selection is mainly done at the queen level. It is therefore essential to develop methods that allow to genotype a colony at a lower cost.
Members
| Pierre Faux | |
| Sylvain Foissac | Webpage |
| Cervin Guyomar | Webpage |
| David Robelin | |
| Bertrand Servin | Webpage |
| Sabrina Legoueix |
| Alice Etourneau | |
| Elise Jorge |
| Elise Tourrette |
| Simon Boitard | |
| Claude Chevalet | |
| Alice Danguy des Déserts | |
| Cyriel Paris | |
| Lucy Peters | |
| Morgane Petit |
Publications
2024
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Cell specification and functional interactions in the pig blastocyst inferred from single-cell transcriptomics and uterine fluids proteomics. Genomics. 2024:110780. doi:10.1016/j.ygeno.2023.110780.
2023
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Genetic diversity and historical demography of underutilised goat breeds in North-Western Europe. Sci Rep. 2023;13(1):20728. doi:10.1038/s41598-023-48005-8.
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A meta-analysis of genetic and phenotypic diversity of European local pig breeds reveals genomic regions associated with breed differentiation for production traits. Genet Sel Evol. 2023;55(1):88. doi:10.1186/s12711-023-00858-3.
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Looking for a needle in a haystack: de novo phenotypic target identification reveals Hippo pathway-mediated miR-202 regulation of egg production. Nucleic Acids Res. 2023. doi:10.1093/nar/gkad1154.
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Identification of runs of homozygosity in Western honey bees () using whole-genome sequencing data. Ecol Evol. 2023;13(1):e9723. doi:10.1002/ece3.9723.
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Enhancer/gene relationships: Need for more reliable genome-wide reference sets. Front Bioinform. 2023;3:1092853. doi:10.3389/fbinf.2023.1092853.
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Comparison of genomic-enabled cross selection criteria for the improvement of inbred line breeding populations. G3 (Bethesda). 2023. doi:10.1093/g3journal/jkad195.
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Neanderthal introgression in SCN9A impacts mechanical pain sensitivity. Commun Biol. 2023;6(1):958. doi:10.1038/s42003-023-05286-z.
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. HLA-F transcriptional and protein differential expression according to its genetic polymorphisms. HLA. 2023;102(5):578-589. doi:10.1111/tan.15087.
2022
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A high-quality functional genome assembly of Delia radicum L. (Diptera: Anthomyiidae) annotated from egg to adult. Mol Ecol Resour. 2022. doi:10.1111/1755-0998.13594.
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