I am interested in the development of inference methods for population genetics, and in their application to farm animal species.
The methods I develop aim at reconstructing the evolution history of species, based on genomic data observed in these species.
They concern both neutral (population size history, population structure ...)
and adaptive (detection of locus under selection, estimation of selection history ...) aspects of this evolution.
I apply these methods to a wide range of plant and animal species,
mostly farm animal species (cattle and sheep essentially) for which I try to decipher the domestication process and the consequences of recent intensive selection.
Phone:
0561285117
Publications
Epilepsy caused by an abnormal alternative splicing with dosage effect of the SV2A gene in a chicken model. PloS one 6, e26932 (2011).
Genetic variability, structure and assignment of Spanish and French pig populations based on a large sampling. Animal genetics 41, 608-18 (2010).
Asymptotic distribution of the "orthogonal" quantitative transmission disequilibrium test in a structured population: exact formula. Statistical applications in genetics and molecular biology 9, Article 11 (2010).
Detecting Selection in Population Trees: The Lewontin and Krakauer Test Extended. Genetics 186, 241-262 (2010).
Detecting selective sweeps: a new approach based on hidden markov models. Genetics 181, 1567-78 (2009).