Title | The duck genome and transcriptome provide insight into an avian influenza virus reservoir species. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Huang, Y, Li, Y, Burt, DW, Chen, H, Zhang, Y, Qian, W, Kim, H, Gan, S, Zhao, Y, Li, J, Yi, K, Feng, H, Zhu, P, Li, B, Liu, Q, Fairley, S, Magor, KE, Du, Z, Hu, X, Goodman, L, Tafer, H, Vignal, A, Lee, T, Kim, K-W, Sheng, Z, An, Y, Searle, S, Herrero, J, Groenen, MAM, Crooijmans, RPMA, Faraut, T, Cai, Q, Webster, RG, Aldridge, JR, Warren, WC, Bartschat, S, Kehr, S, Marz, M, Stadler, PF, Smith, J, Kraus, RHS, Zhao, Y, Ren, L, Fei, J, Morisson, M, Kaiser, P, Griffin, DK, Rao, M, Pitel, F, Wang, J, Li, N |
Journal | Nat Genet |
Volume | 45 |
Issue | 7 |
Pagination | 776-83 |
Date Published | 2013 Jul |
ISSN | 1546-1718 |
Keywords | Animals, Base Sequence, Chickens, Disease Reservoirs, Disease Vectors, Ducks, Female, Geese, Genome, Host-Pathogen Interactions, Immunity, Influenza in Birds, Molecular Sequence Data, Phylogeny, Species Specificity, Transcriptome |
Abstract | The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses. |
DOI | 10.1038/ng.2657 |
Alternate Journal | Nat. Genet. |
PubMed ID | 23749191 |
PubMed Central ID | PMC4003391 |
Grant List | 079643 / / Wellcome Trust / United Kingdom 095908 / / Wellcome Trust / United Kingdom BB/I025328/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom BB/I025360/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom BB/I025506/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom BB/K008161/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom BBS/E/D/20211550 / / Biotechnology and Biological Sciences Research Council / United Kingdom BBS/E/D/20211552 / / Biotechnology and Biological Sciences Research Council / United Kingdom BBS/E/D/20241863 / / Biotechnology and Biological Sciences Research Council / United Kingdom BBS/E/D/20320000 / / Biotechnology and Biological Sciences Research Council / United Kingdom |
The duck genome and transcriptome provide insight into an avian influenza virus reservoir species.
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