Post-Doc

transgenerational non-genetic inheritance

The GenPhySE unit invites applications for a Postdoctoral Research position as part of the European GEroNIMO project (https://www.geronimo-h2020.eu/).

The position is a full-time fixed-term appointment of 2 years (https://jobs.inrae.fr/en/ot-19208). The start date is March 2024 (flexible).

For more information please contact ingrid.david@inrae.fr, enclosing - if you wish to apply - a cover letter, letters of recommendation, statement of research interests, updated CV.

genetic improvement of robustness in pigs

As part of the flaghip cobreeding project of the PEPR agroécologie et numérique, the UMR GenPhySE is offering a postdoctoral position on the genetic improvement of robustness in pigs.

The position is a full-time fixed-term appointment of 2 years (https://jobs.inrae.fr/en/ot-19207). The start date is September 2024 (flexible).

For more information please contact ingrid.david@inrae.fr, enclosing - if you wish to apply - a cover letter, letters of recommendation, statement of research interests, updated CV.

DNA methylation editing in intestinal epithelial cells

KEY WORDS
DNA methylation, epigenetics, CRISPR, digestive system, RNA transfection

WORKING ENVIRONMENT AND ACTIVITIES
You will be based in the "Genetics, Physiology and Farming Systems" joint research unit, in a team
working on the genetic and epigenetic determinism of traits in farm animal species.
The aim of this post-doctorate is to develop epigenome editing (notably DNA methylation) in
cellular models of the pig digestive epithelium in order to repress the expression of target genes of interest
for intestinal barrier function. These epigenomic editing tools could then be used in the future for
functional genomics studies on cellular models, in order to limit the need for animal experimentation.
Epigenome editing tools are mainly available in the form of plasmids for DNA transfections. They
are based on the targeting by a guide RNA of an inactivated Cas9 (dCas9) coupled to one or more
epigenetic enzymes (e.g. methyltransferases). Our cell models require high transfection efficiencies, which
are more easily achieved by transfection of messenger RNA. You will therefore adapt and optimise existing
plasmids for in vitro transcription, while studying the efficiency and specificity of epigenome editing
inductions. Among the possible optimisations you will explore are:

Post-doctoral research position on epigenetic footprints of environmental changes and epigenetic inheritance

GenPhySE research unit, INRAE, Toulouse, France GenPhySE

Applications are invited for a Postdoctoral Research position as part of the GEroNIMO project (European Horizon 2020), entitled "Genome and epigenome enabled breeding in monogastrics" (GEroNIMO).
The position is a full-time fixed-term appointment of 3 years with opportunity for a 1-year extension

GEroNIMO is a large scale project involving 21 partners from 11 European Countries that aims to provide chicken and pig breeders with new knowledge and tools to promote innovative genome- and epigenome enabled selection methods, to move toward more sustainable breeding models. GEroNIMO is part of the EuroFAANG effort (EuroFAANG).
The successful candidate will lead projects using epigenetic data obtained from large pig and chicken populations to study the genetic and epigenetic contributions to phenotypic variation, to assess DNA methylation footprints of selection and of environmental factors, and to estimate the extent of transgenerational epigenetic inheritance. Great opportunities to publish!
She/he will be based in Toulouse at INRAE and will join a multi-disciplinary environment of geneticists, bioinformaticians and biostatisticians. The successful candidate will take a leading role in the data analysis and will be expected to use her/his initiative and creativity to identify areas for research development.

Ingénieur(e) de recherche en biostatistiques et intégration de données omiques

L’Institut national de recherche pour l’agriculture, l’alimentation et l’environnement (INRAE) est un établissement public de recherche rassemblant une communauté de travail de 12 000 personnes, avec 268 unités de recherche, de service et expérimentales, implantées dans 18 centres sur toute la France. INRAE se positionne parmi les tout premiers leaders mondiaux en sciences agricoles et alimentaires, en sciences du végétal et de l’animal. Ses recherches visent à construire des solutions pour des agricultures multi-performantes, une alimentation de qualité et une gestion durable des ressources et des écosystèmes.

VOTRE MISSION ET VOS ACTIVITÉS

Vous serez accueilli(e) au sein de l’unité mixte de recherche GenPhySE : Génétique, Physiologie et Systèmes d’Elevage (UMR INRA/ENVT/ENSAT) réunissant les compétences de généticiens quantitatifs et moléculaires, de biologistes cellulaires, de physiologistes et de mathématiciens. L’unité est constituée de 147 permanents et est structurée en 10 équipes. Son objectif est d’améliorer la connaissance des génomes des animaux domestiques au niveau structural et fonctionnel, d’étudier et gérer la composante génétique des principaux caractères d’intérêt agronomique, d’élaborer des systèmes d’élevage innovants et durables.

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