Accounting for overlapping annotations in genomic prediction models of complex traits.

TitleAccounting for overlapping annotations in genomic prediction models of complex traits.
Publication TypeJournal Article
Year of Publication2022
AuthorsMollandin, F, Gilbert, H, Croiseau, P, Rau, A
JournalBMC Bioinformatics
Date Published2022 Sep 06
KeywordsBayes Theorem, Genomics, Genotype, Models, Genetic, Multifactorial Inheritance, Phenotype, Polymorphism, Single Nucleotide

BACKGROUND: It is now widespread in livestock and plant breeding to use genotyping data to predict phenotypes with genomic prediction models. In parallel, genomic annotations related to a variety of traits are increasing in number and granularity, providing valuable insight into potentially important positions in the genome. The BayesRC model integrates this prior biological information by factorizing the genome according to disjoint annotation categories, in some cases enabling improved prediction of heritable traits. However, BayesRC is not adapted to cases where markers may have multiple annotations.

RESULTS: We propose two novel Bayesian approaches to account for multi-annotated markers through a cumulative (BayesRC+) or preferential (BayesRC[Formula: see text]) model of the contribution of multiple annotation categories. We illustrate their performance on simulated data with various genetic architectures and types of annotations. We also explore their use on data from a backcross population of growing pigs in conjunction with annotations constructed using the PigQTLdb. In both simulated and real data, we observed a modest improvement in prediction quality with our models when used with informative annotations. In addition, our results show that BayesRC+ successfully prioritizes multi-annotated markers according to their posterior variance, while BayesRC[Formula: see text] provides a useful interpretation of informative annotations for multi-annotated markers. Finally, we explore several strategies for constructing annotations from a public database, highlighting the importance of careful consideration of this step.

CONCLUSION: When used with annotations that are relevant to the trait under study, BayesRC[Formula: see text] and BayesRC+ allow for improved prediction and prioritization of multi-annotated markers, and can provide useful biological insight into the genetic architecture of traits.

Alternate JournalBMC Bioinformatics
PubMed ID36068513
PubMed Central IDPMC9446854
Grant List817998 / / H2020 European Research Council /
815668 / / H2020 European Research Council /
817998 / / H2020 European Research Council /
ANR-12-ADAP-0015 / / Agence Nationale de la Recherche /