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The sterlet sturgeon genome sequence and the mechanisms of segmental rediploidization.

TitleThe sterlet sturgeon genome sequence and the mechanisms of segmental rediploidization.
Publication TypeJournal Article
Year of Publication2020
AuthorsDu, K, Stöck, M, Kneitz, S, Klopp, C, Woltering, JM, Adolfi, MContar, Feron, R, Prokopov, D, Makunin, A, Kichigin, I, Schmidt, C, Fischer, P, Kuhl, H, Wuertz, S, Gessner, J, Kloas, W, Cabau, C, Iampietro, C, Parrinello, H, Tomlinson, C, Journot, L, Postlethwait, JH, Braasch, I, Trifonov, V, Warren, WC, Meyer, A, Guiguen, Y, Schartl, M
JournalNat Ecol Evol
Volume4
Issue6
Pagination841-852
Date Published2020 06
ISSN2397-334X
KeywordsAnimals, Chromosomes, Fishes, Genome, Phylogeny, Polyploidy
Abstract

Sturgeons seem to be frozen in time. The archaic characteristics of this ancient fish lineage place it in a key phylogenetic position at the base of the ~30,000 modern teleost fish species. Moreover, sturgeons are notoriously polyploid, providing unique opportunities to investigate the evolution of polyploid genomes. We assembled a high-quality chromosome-level reference genome for the sterlet, Acipenser ruthenus. Our analysis revealed a very low protein evolution rate that is at least as slow as in other deep branches of the vertebrate tree, such as that of the coelacanth. We uncovered a whole-genome duplication that occurred in the Jurassic, early in the evolution of the entire sturgeon lineage. Following this polyploidization, the rediploidization of the genome included the loss of whole chromosomes in a segmental deduplication process. While known adaptive processes helped conserve a high degree of structural and functional tetraploidy over more than 180 million years, the reduction of redundancy of the polyploid genome seems to have been remarkably random.

DOI10.1038/s41559-020-1166-x
Alternate JournalNat Ecol Evol
PubMed ID32231327
PubMed Central IDPMC7269910
Grant ListR01 OD011116 / OD / NIH HHS / United States