Characterization of porcine ASB6 gene and transcripts-comparison of mammalian transcripts.

TitleCharacterization of porcine ASB6 gene and transcripts-comparison of mammalian transcripts.
Publication TypeJournal Article
Year of Publication2008
AuthorsRobic, A, Faraut, T, Liaubet, L, Riquet, J, Milan, D, Lobjois, V
JournalAnim Biotechnol
Date Published2008
KeywordsAlternative Splicing, Amino Acid Sequence, Animals, Ankyrin Repeat, Base Sequence, Cattle, DNA, Complementary, Expressed Sequence Tags, Humans, Introns, Mice, Molecular Sequence Data, Muscle, Skeletal, Polymerase Chain Reaction, Rats, Sequence Alignment, Sequence Analysis, DNA, Suppressor of Cytokine Signaling Proteins, Sus scrofa, Transcription, Genetic

A member of the porcine Ankyrin repeat and suppressor of cytokine signaling (SOCS) Box protein family (ASB), designed as ASB6, was sequenced and the genomic organization of the six exons was determined. We present here a detailed analysis of ASB6 transcripts in pigs. We demonstrate the existence of an alternative transcript resulting from intron retention. This secondary transcript, if functional, encodes a protein without SOCS box. A comparison of mammalian ASB6 transcripts is performed to demonstrate the importance of transcripts encoding for a truncated ASB6 protein.

Alternate JournalAnim. Biotechnol.
PubMed ID18607786