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The maturity in fetal pigs using a multi-fluid metabolomic approach.

TitleThe maturity in fetal pigs using a multi-fluid metabolomic approach.
Publication TypeJournal Article
Year of Publication2020
AuthorsLefort, G, Servien, R, Quesnel, H, Billon, Y, Canario, L, Iannuccelli, N, Canlet, C, Paris, A, Vialaneix, N, Liaubet, L
JournalSci Rep
Volume10
Issue1
Pagination19912
Date Published2020 11 16
ISSN2045-2322
Abstract

In mammalian species, the first days after birth are an important period for survival and the mortality rate is high before weaning. In pigs, perinatal deaths average 20% of the litter, with important economic and societal consequences. Maturity is one of the most important factors that influence piglet survival at birth. Maturity can be defined as the outcome of complex mechanisms of intra-uterine development and maturation during the last month of gestation. Here, we provide new insights into maturity obtained by studying the end of gestation at two different stages (3 weeks before term and close to term) in two breeds of pigs that strongly differ in terms of neonatal survival. We used metabolomics to characterize the phenotype, to identify biomarkers, and provide a comprehensive understanding of the metabolome of the fetuses in late gestation in three fluids (plasma, urine, and amniotic fluid). Our results show that the biological processes related to amino acid and carbohydrate metabolisms are critical for piglet maturity. We confirm the involvement of some previously described metabolites associated with delayed growth (e.g., proline and myo-inositol). Altogether, our study proposes new routes for improved characterization of piglet maturity at birth.

DOI10.1038/s41598-020-76709-8
Alternate JournalSci Rep
PubMed ID33199811
PubMed Central IDPMC7670440