|Title||Early Inoculation of Microbial Suspension in Suckling Piglets Affects the Transmission of Maternal Microbiota and the Associated Antibiotic Resistance Genes.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Achard, CS, Dupouy, V, Cauquil, L, Arpaillange, N, Bousquet-Melou, A, Le Floc'h, N, Zemb, O|
|Date Published||2020 Oct 13|
Antibiotic resistance of microbes thriving in the animal gut is a growing concern for public health as it may serve as a hidden reservoir for antibiotic resistance genes (ARGs). We compared 16 control piglets to 24 piglets fed for 3 weeks with S1 or S2 fecal suspensions from two sows that were not exposed to antibiotics for at least 6 months: the first suspension decreased the erythromycin resistance gene and the aminoglycoside phosphotransferase gene conferring resistance to kanamycine , while the second decreased the tetracycline resistance gene , with an unexpected increase in ARGs. Using 16S RNA sequencing, we identified microbial species that are likely to carry ARGs, such as the lincosamide nucleotidyltransferase , the cephalosporinase , and the tetracycline resistance genes and , as well as microbes that never co-exist with the tetracycline resistance gene , the erythromycin resistance gene and . Since 73% of the microbes detected in the sows were not detected in the piglets at weaning, a neutral model was applied to estimate whether a microbial species is more important than chance would predict. This model confirmed that force-feeding modifies the dynamics of gut colonization. In conclusion, early inoculation of gut microbes is an interesting possibility to stimulate gut microbiota towards a desirable state in pig production, but more work is needed to be able to predict which communities should be used.
|Grant List||microreset / / Institut Carnot Santé Animale /|