Title | Analysis of Meiotic Segregation Pattern and Interchromosomal Effects in a Bull Heterozygous for a 3/16 Robertsonian Translocation. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Barasc, H, Mouney-Bonnet, N, Peigney, C, Calgaro, A, Revel, C, Mary, N, Ducos, A, Pinton, A |
Journal | Cytogenet Genome Res |
Volume | 156 |
Issue | 4 |
Pagination | 197-203 |
Date Published | 2018 |
ISSN | 1424-859X |
Keywords | Animals, Cattle, Chromosome Segregation, Chromosomes, Mammalian, Cytogenetic Analysis, In Situ Hybridization, Fluorescence, Male, Meiosis, Spermatozoa, Translocation, Genetic |
Abstract | Robertsonian translocations are the most frequent chromosomal rearrangements detected in cattle. Here, we report on the detection of a new Robertsonian translocation between chromosomes BTA3 and BTA16. This rob(3;16) was dicentric, suggesting that its occurrence was recent. FISH analysis of decondensed sperm nuclei revealed a relatively low rate of unbalanced gametes produced by adjacent segregation (5.87%). In addition, and for the first time in bovines, a significant interchromosomal effect (ICE) was detected for 2 different autosomes: BTA17 (global disomy + nullisomy rate of 9%) and BTA20 (1.8%). These results suggest that ICE should be taken into consideration when assessing the putative effect of Robertsonian translocations on reproduction. |
DOI | 10.1159/000494289 |
Alternate Journal | Cytogenet. Genome Res. |
PubMed ID | 30504703 |
Analysis of Meiotic Segregation Pattern and Interchromosomal Effects in a Bull Heterozygous for a 3/16 Robertsonian Translocation.
cytogene