|Title||Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Bouwman, AC, Daetwyler, HD, Chamberlain, AJ, Ponce, CHurtado, Sargolzaei, M, Schenkel, FS, Sahana, G, Govignon-Gion, A, Boitard, S, Dolezal, M, Pausch, H, Brøndum, RF, Bowman, PJ, Thomsen, B, Guldbrandtsen, B, Lund, MS, Servin, B, Garrick, DJ, Reecy, J, Vilkki, J, Bagnato, A, Wang, M, Hoff, JL, Schnabel, RD, Taylor, JF, Vinkhuyzen, AAE, Panitz, F, Bendixen, C, Holm, L-E, Gredler, B, Hozé, C, Boussaha, M, Sanchez, M-P, Rocha, D, Capitan, A, Tribout, T, Barbat, A, Croiseau, P, Drögemüller, C, Jagannathan, V, Jagt, CVander, Crowley, JJ, Bieber, A, Purfield, DC, Berry, DP, Emmerling, R, Götz, K-U, Frischknecht, M, Russ, I, Sölkner, J, Van Tassell, CP, Fries, R, Stothard, P, Veerkamp, RF, Boichard, D, Goddard, ME, Hayes, BJ|
|Date Published||2018 Mar|
Stature is affected by many polymorphisms of small effect in humans. In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes. Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 × 10) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP-seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals.
|Alternate Journal||Nat. Genet.|