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Regulation of ovulation rate in mammals: contribution of sheep genetic models

TitleRegulation of ovulation rate in mammals: contribution of sheep genetic models
Publication TypeJournal Article
Year of Publication2006
AuthorsFabre, S, Pierre, A, Mulsant, P, Bodin, L, Di Pasquale, E, Persani, L, Monget, P, Monniaux, D
JournalReprod Biol Endocrinol
Volume4
Pagination20
Keywords*Models, Animals, Female, Genetic, Mammals/*physiology, Ovulation/*physiology, Sheep/*genetics
Abstract

Ovarian folliculogenesis in mammals from the constitution of primordial follicles up to ovulation is a reasonably well understood mechanism. Nevertheless, underlying mechanisms that determine the number of ovulating follicles were enigmatic until the identification of the fecundity genes affecting ovulation rate in sheep, bone morphogenetic protein-15 (BMP-15), growth and differentiation factor-9 (GDF-9) and BMP receptor-1B (BMPR-1B). In this review, we focus on the use of these sheep genetic models for understanding the role of the BMP system as an intra-ovarian regulator of follicular growth and maturation, and finally, ovulation rate.

URLhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16611365