GenoRobust Research Activities

Our research aims to identify levers to increase the robustness of animals by restoring a better balance between production and adaptability. In this context, we analyze the genetic architecture of stress response systems (particularly the HPA axis) and metabolic processes involved in the balance between production and adaptation (especially energy metabolism of muscle and liver), and epigenetic mechanisms that influence them. The approach is integrative (system biology and genetics) and interdisciplinary (genetics and epigenetics, metabolic and neuroendocrine physiology, genomics and bioinformatics, biomathematics).
Team projects relate mainly to two species of agronomic interest, pig and duck, and also some model species (mouse, rat, chicken, human). Our approaches are both focused on traits of interest and on deciphering the underlying mechanisms, particularly genetic and epigenetic regulating these traits.

Our three research axes are:

  • Axis 1: Genetic control of the variability of the HPA axis in the center of the regulation of stress responses
    • Molecular genetics of stress response and robustness in the pig
    • Adaptation of ducks to force feeding, objective "zero" mortality
  • Axis 2: Genetic and physiological determinism of the variability of production and functional traits
    • Integrated approach of maturity (status of full development for survival at birth) in connection with piglet neonatal survival
    • Detection of QTL, eQTL, pQTL, mQTL for production traits (pig and duck)
    • Genetic diversity (transcriptome and metabolome) of different pig lines
  • Axis 3: Impact of early environment on metabolic programming and related production and functional traits
    • Fetal-maternal exchange, dialogue between two genomes and impact of maternal metabolism on the survival of piglets.
    • Impact of a methionine deficiency of the female duck on the development of fatty liver in the progeny.