Azoospermia and Testicular Hypoplasia in a Boar Carrier of a Novel Y-Autosome Translocation.

TitleAzoospermia and Testicular Hypoplasia in a Boar Carrier of a Novel Y-Autosome Translocation.
Publication TypeJournal Article
Year of Publication2017
AuthorsVillagómez, DAF, Revay, T, Donaldson, B, Rezaei, S, Pinton, A, Palomino, M, Junaidi, A, Honaramooz, A, W King, A
JournalSex Dev
Volume11
Issue1
Pagination46-51
Date Published2017
ISSN1661-5433
Abstract

Few sex-autosome chromosome abnormalities have been documented in domestic animal species. In humans, Y-autosome chromosome abnormalities may occur at a rate of 1/2,000 live births, whereas in the domestic pig only 2 Y-autosome reciprocal translocations have been previously described. During a routine cytogenetic screening of young boars, we identified a new Y-autosome translocation carrier, which after puberty showed semen devoid of sperm and testicular hypoplasia with spermatogenesis arrest. Whole chromosome painting by FISH analysis corroborated the reciprocal nature of the chromosomal exchanges between the Y chromosome and SSC13. The possible causes for the observed meiotic arrest of the carrier are reviewed.

DOI10.1159/000453298
Alternate JournalSex Dev
PubMed ID27974725